TRF1 Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Highly expressed and ubiquitous. Isoform Pin2 predominates. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1 A3|1 4.88 cM
Cellular Component:  chromosome; chromosome, telomeric region; cytoplasm; cytoskeleton; fibrillar center; nuclear body; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleus; shelterin complex
Molecular Function:  ankyrin repeat binding; DNA binding; DNA binding, bending; double-stranded telomeric DNA binding; G-rich strand telomeric DNA binding; microtubule binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; telomeric DNA binding
Biological Process:  cell cycle; cell division; meiotic telomere clustering; mitotic spindle assembly checkpoint; negative regulation of DNA replication; negative regulation of establishment of protein localization to telomere; negative regulation of establishment of RNA localization to telomere; negative regulation of exonuclease activity; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of telomeric D-loop disassembly; positive regulation of apoptotic process; positive regulation of microtubule polymerization; positive regulation of mitotic cell cycle; positive regulation of mitotic nuclear division; positive regulation of shelterin complex assembly; protein homooligomerization; telomere maintenance; telomere maintenance via telomerase; telomeric D-loop disassembly
Reference #:  P70371 (UniProtKB)
Alt. Names/Synonyms: Pin2; telomeric repeat binding factor 1; Telomeric repeat-binding factor 1; Terf1; Trbf1; Trf1; TTAGGG repeat-binding factor 1
Gene Symbols: Terf1
Molecular weight: 48,224 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
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TRF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene