Cofilin-1 Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  actin cytoskeleton; cell leading edge; cell projection; cell-cell junction; cofilin-actin rod; cortical actin cytoskeleton; cytoplasm; cytoskeleton; dendritic spine; filopodium; focal adhesion; glutamatergic synapse; growth cone; lamellipodium; membrane; mitochondrial membrane; neuron projection; neuronal cell body; nucleus; plasma membrane; synaptic membrane
Molecular Function:  actin binding; actin filament binding; phosphatidylinositol bisphosphate binding; protein phosphatase binding; signaling receptor binding
Biological Process:  actin filament depolymerization; actin filament fragmentation; actin filament organization; cell projection organization; cellular response to epidermal growth factor stimulus; cellular response to hydrogen peroxide; cellular response to insulin-like growth factor stimulus; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to tumor necrosis factor; cytoskeleton organization; establishment of cell polarity; mitotic cytokinesis; modification of postsynaptic actin cytoskeleton; negative regulation of actin filament bundle assembly; negative regulation of actin filament depolymerization; negative regulation of cell adhesion; negative regulation of cell motility; negative regulation of cell size; negative regulation of dendritic spine maintenance; negative regulation of lamellipodium assembly; negative regulation of postsynaptic density organization; negative regulation of unidimensional cell growth; neural crest cell migration; neural fold formation; positive regulation by host of viral process; positive regulation of actin filament depolymerization; positive regulation of barbed-end actin filament capping; positive regulation of cell growth; positive regulation of cell motility; positive regulation of dendritic spine development; positive regulation of establishment of cell polarity regulating cell shape; positive regulation of focal adhesion assembly; positive regulation of lamellipodium assembly; positive regulation of NMDA glutamate receptor activity; positive regulation of protein localization to cell leading edge; positive regulation of proteolysis; positive regulation of synaptic plasticity; protein import into nucleus; protein phosphorylation; regulation of cell morphogenesis; regulation of dendritic spine morphogenesis; response to amino acid
Reference #:  P18760 (UniProtKB)
Alt. Names/Synonyms: AA959946; Cfl1; Cof; COF1; cofilin 1, non-muscle; Cofilin, non-muscle isoform; Cofilin-1; n-c; n-cofilin
Gene Symbols: Cfl1
Molecular weight: 18,560 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA