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LMCD1
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 3p25.3 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
protein binding; transcription corepressor activity; zinc ion binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; positive regulation of calcineurin-NFAT signaling cascade; regulation of cardiac muscle hypertrophy
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Reference #:
Q9NZU5
(UniProtKB)
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Alt. Names/Synonyms: Dyxin; LIM and cysteine rich domains 1; LIM and cysteine-rich domains 1; LIM and cysteine-rich domains protein 1; LMCD1
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Gene Symbols: LMCD1
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Molecular weight:
40,833 Da
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Basal Isoelectric point:
8.27
Predict pI for various phosphorylation states
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