SLC27A4 Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family. Note: This description may include information from UniProtKB.
Protein type: EC 6.2.1.-; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component:  brush border membrane; endoplasmic reticulum membrane; integral component of membrane; plasma membrane
Molecular Function:  long-chain fatty acid-CoA ligase activity; nucleotide binding; very long-chain fatty acid-CoA ligase activity
Biological Process:  long-chain fatty acid import; long-chain fatty acid metabolic process; long-chain fatty acid transport; skin development
Disease: Ichthyosis Prematurity Syndrome
Reference #:  Q6P1M0 (UniProtKB)
Alt. Names/Synonyms: ACSVL4; FATP-4; FATP4; Fatty acid transport protein 4; IPS; Long-chain fatty acid transport protein 4; S27A4; SLC27A4; solute carrier family 27 (fatty acid transporter), member 4; Solute carrier family 27 member 4
Gene Symbols: SLC27A4
Molecular weight: 72,064 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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