SLC27A4
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. Belongs to the ATP-dependent AMP-binding enzyme family. Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 6.2.1.-; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
Chromosomal Location of human Ortholog: 9q34.11 |
Cellular Component:
brush border membrane; endoplasmic reticulum; endoplasmic reticulum membrane; microvillus; plasma membrane
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Molecular Function:
arachidonate-CoA ligase activity; fatty acid transmembrane transporter activity; long-chain fatty acid transporter activity; long-chain fatty acid-CoA ligase activity; nucleotide binding; oleate transmembrane transporter activity; oleoyl-CoA ligase activity; palmitoyl-CoA ligase activity; very long-chain fatty acid-CoA ligase activity
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Biological Process:
activation of GTPase activity; establishment of localization in cell; fatty acid metabolic process; fatty acid transport; glucose import in response to insulin stimulus; lipid transport across blood-brain barrier; long-chain fatty acid import into cell; long-chain fatty acid metabolic process; long-chain fatty acid transport; medium-chain fatty acid transport; negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity; negative regulation of insulin receptor signaling pathway; positive regulation of apoptotic process; response to nutrient; skin development; transport across blood-brain barrier; very long-chain fatty acid catabolic process
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Disease: Ichthyosis Prematurity Syndrome
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Reference #:
Q6P1M0
(UniProtKB)
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Alt. Names/Synonyms: ACSVL4; Arachidonate--CoA ligase; FATP-4; FATP4; Fatty acid transport protein 4; IPS; Long-chain fatty acid transport protein 4; Long-chain-fatty-acid--CoA ligase; S27A4; SLC27A4; solute carrier family 27 (fatty acid transporter), member 4; Solute carrier family 27 member 4; Very long-chain acyl-CoA synthetase 4
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Gene Symbols: SLC27A4
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Molecular weight:
72,064 Da
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Basal Isoelectric point:
8.77
Predict pI for various phosphorylation states
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