LDB3
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cytoskeletal |
Chromosomal Location of mouse Ortholog: 14|14 B |
Cellular Component:
adherens junction; cell projection; cytoplasm; cytoskeleton; filamentous actin; stress fiber; Z disc
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Molecular Function:
actin binding; cytoskeletal protein binding; enzyme binding; metal ion binding; muscle alpha-actinin binding; protein binding; protein kinase C binding
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Biological Process:
actin cytoskeleton organization; heart development; muscle structure development; sarcomere organization
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Reference #:
Q9JKS4
(UniProtKB)
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Alt. Names/Synonyms: AW742271; cyph; cypher; Kiaa0613; Ldb3; LIM domain binding 3; LIM domain-binding protein 3; MGC118603; oracle protein; PDLIM6; PDZ-LIM domain protein; Protein cypher; Protein oracle; Z-band alternatively spliced PDZ-motif protein; ZASP
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Gene Symbols: Ldb3
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Molecular weight:
76,432 Da
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Basal Isoelectric point:
7.96
Predict pI for various phosphorylation states
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