TEP1 Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component:  chromosome, telomeric region; cytoplasm; nuclear matrix; ribonucleoprotein complex; telomerase holoenzyme complex
Molecular Function:  ATP binding; enzyme binding; p53 binding; RNA binding; telomerase RNA binding
Biological Process:  RNA-dependent DNA biosynthetic process; telomere maintenance via recombination
Reference #:  Q99973 (UniProtKB)
Alt. Names/Synonyms: p240; p80 telomerase homolog; Telomerase protein 1; Telomerase protein component 1; Telomerase-associated protein 1; TEP1; TLP1; TP1; TROVE domain family, member 1; TROVE1; VAULT2
Gene Symbols: TEP1
Molecular weight: 290,490 Da
Basal Isoelectric point: 8.26  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB