TCF2 Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Belongs to the HNF1 homeobox family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q12
Cellular Component:  nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; protein homodimerization activity; protein-containing complex binding; proximal promoter sequence-specific DNA binding
Biological Process:  anterior/posterior pattern specification; branching morphogenesis of an epithelial tube; circadian regulation of gene expression; embryonic digestive tract morphogenesis; endodermal cell fate specification; epithelial cell proliferation; hepatoblast differentiation; hepatocyte differentiation; hindbrain development; inner cell mass cell differentiation; insulin secretion; kidney development; mesonephric duct formation; negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; pancreas development; positive regulation of transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; pronephric nephron tubule development; pronephros development; protein-DNA complex assembly; regulation of branch elongation involved in ureteric bud branching; regulation of endodermal cell fate specification; regulation of pronephros size; regulation of Wnt signaling pathway; response to drug; response to glucose; response to organic cyclic compound; ureteric bud elongation
Disease: Diabetes Mellitus, Noninsulin-dependent; Renal Cell Carcinoma, Nonpapillary; Renal Cysts And Diabetes Syndrome
Reference #:  P35680 (UniProtKB)
Alt. Names/Synonyms: FJHN; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; HNF1 homeobox B; HNF1B; HNF1beta; HNF2; Homeoprotein LFB3; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; Transcription factor 2; transcription factor 2, hepatic; Variant hepatic nuclear factor 1; vHNF1
Gene Symbols: HNF1B
Molecular weight: 61,324 Da
Basal Isoelectric point: 7.39  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein