UBF a transcription factor that recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. Activate RNA polymerase II-regulated, beta-catenin-responsive promoters. Interacts with TAF1, a factor involved in the transcription of cell cycle and growth regulatory genes. It binds specifically to the upstream control element. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Transcription factor
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  fibrillar center; nucleolus; nucleus
Molecular Function:  chromatin binding; DNA binding; protein binding; RNA polymerase I CORE element sequence-specific DNA binding; RNA polymerase I upstream control element sequence-specific DNA binding; scaffold protein binding
Biological Process:  cellular response to leukemia inhibitory factor; chromatin silencing at rDNA; positive regulation of transcription by RNA polymerase I; transcription by RNA polymerase I; transcription elongation from RNA polymerase I promoter
Reference #:  P25976 (UniProtKB)
Alt. Names/Synonyms: A930005G04Rik; NOR-90; Nucleolar transcription factor 1; OTTMUSP00000002630; OTTMUSP00000002631; OTTMUSP00000002632; OTTMUSP00000002633; Tcfubf; transcription factor UBF; UBF; UBF-1; Ubf1; Ubtf; upstream binding transcription factor, RNA polymerase I; Upstream-binding factor 1
Gene Symbols: Ubtf
Molecular weight: 89,509 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene