APCS
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. Belongs to the pentraxin family. Found in serum and urine. Note: This description may include information from UniProtKB.
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Protein type: Chaperone; Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 1q23.2 |
Cellular Component:
extracellular region; extracellular space
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Molecular Function:
calcium ion binding; carbohydrate binding; complement component C1q complex binding; identical protein binding; protein binding; unfolded protein binding; virion binding
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Biological Process:
acute-phase response; chaperone-mediated protein complex assembly; innate immune response; negative regulation by host of viral exo-alpha-sialidase activity; negative regulation by host of viral glycoprotein metabolic process; negative regulation of acute inflammatory response; negative regulation of exo-alpha-sialidase activity; negative regulation of glycoprotein metabolic process; negative regulation of monocyte differentiation; negative regulation of viral entry into host cell; negative regulation of viral process; negative regulation of wound healing; protein folding
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Reference #:
P02743
(UniProtKB)
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Alt. Names/Synonyms: 9.5S alpha-1-glycoprotein; amyloid P component, serum; APCS; epididymis secretory sperm binding protein Li 92n; HEL-S-92n; MGC88159; pentaxin-related; pentraxin-2; pentraxin-related; PTX2; SAMP; SAP; Serum amyloid P-component; Serum amyloid P-component(1-203)
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Gene Symbols: APCS
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Molecular weight:
25,387 Da
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Basal Isoelectric point:
6.1
Predict pI for various phosphorylation states
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