PRSS7 Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.9; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 21q21.1
Cellular Component:  brush border; integral component of membrane
Molecular Function:  protein binding; scavenger receptor activity; serine-type endopeptidase activity
Biological Process:  proteolysis; receptor-mediated endocytosis
Disease: Enterokinase Deficiency
Reference #:  P98073 (UniProtKB)
Alt. Names/Synonyms: Enterokinase; Enteropeptidase; Enteropeptidase catalytic light chain; Enteropeptidase non-catalytic heavy chain; ENTK; MGC133046; protease, serine, 7 (enterokinase); PRSS7; Serine protease 7; TMPRSS15; transmembrane protease, serine 15
Gene Symbols: TMPRSS15
Molecular weight: 112,935 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
Select Structure to View Below

PRSS7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB