VAV1 Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Widely expressed in hematopoietic cells but not in other cell types. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 17 D|17 29.76 cM
Cellular Component:  cell-cell junction
Molecular Function:  guanyl-nucleotide exchange factor activity; metal ion binding; phosphotyrosine residue binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process:  G protein-coupled receptor signaling pathway; immune response; integrin-mediated signaling pathway; intracellular signal transduction; neutrophil chemotaxis; phagocytosis; positive regulation of cell adhesion; positive regulation of GTPase activity; positive regulation of natural killer cell mediated cytotoxicity; reactive oxygen species metabolic process; regulation of GTPase activity; regulation of Rho protein signal transduction; small GTPase mediated signal transduction; T cell activation; T cell differentiation
Reference #:  P27870 (UniProtKB)
Alt. Names/Synonyms: p95vav; Proto-oncogene vav; Vav; vav 1 oncogene; vav oncogene; vav-T; Vav1
Gene Symbols: Vav1
Molecular weight: 98,137 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene