Yes Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of mouse Ortholog: 5 B1|5 17.33 cM
Cellular Component:  actin filament; cytoplasm; cytoskeleton; cytosol; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; Golgi apparatus; membrane; plasma membrane; postsynaptic specialization, intracellular component
Molecular Function:  ATP binding; enzyme binding; epidermal growth factor receptor binding; ion channel binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine residue binding; protein binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; transferase activity
Biological Process:  cell differentiation; cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; peptidyl-tyrosine autophosphorylation; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein phosphorylation; regulation of glucose transmembrane transport; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q04736 (UniProtKB)
Alt. Names/Synonyms: AI323763; p61-Yes; Proto-oncogene c-Yes; Proto-oncogene tyrosine-protein kinase Yes; Tyrosine-protein kinase Yes; viral oncogene yes homolog; Yamaguchi sarcoma viral (v-yes) oncogene homolog 1; Yes; YES proto-oncogene 1, Src family tyrosine kinase; Yes1
Gene Symbols: Yes1
Molecular weight: 60,630 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein