HMGCS2
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the thiolase-like superfamily. HMG-CoA synthase family. Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain. The relative expression of isoform 3 (at mRNA level) is highest in heart (70%) and skeletal muscle (60%). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase |
Chromosomal Location of mouse Ortholog: 3 F2.2|3 42.74 cM |
Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
acyltransferase activity; hydroxymethylglutaryl-CoA synthase activity; identical protein binding; transferase activity
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Biological Process:
acetyl-CoA metabolic process; cholesterol biosynthetic process; cholesterol metabolic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; ketone body biosynthetic process; lipid metabolic process; steroid biosynthetic process; steroid metabolic process; sterol biosynthetic process
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Reference #:
P54869
(UniProtKB)
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Alt. Names/Synonyms: 1300002P16; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2; HMCS2; HMG-CoA synthase; Hmgcs2; Hydroxymethylglutaryl-CoA synthase, mitochondrial; mHS
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Gene Symbols: Hmgcs2
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Molecular weight:
56,823 Da
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Basal Isoelectric point:
8.65
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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