HERC2 E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Mitochondrial; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 15q13.1
Cellular Component:  centriole; cytoplasm; nucleoplasm; nucleus
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; SUMO binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  cellular response to DNA damage stimulus; double-strand break repair via nonhomologous end joining; intracellular protein transport; protein ubiquitination; spermatogenesis
Disease: Mental Retardation, Autosomal Recessive 38; Prader-willi Syndrome; Skin/hair/eye Pigmentation, Variation In, 1
Reference #:  O95714 (UniProtKB)
Alt. Names/Synonyms: D15F37S1; DKFZp547P028; E3 ubiquitin-protein ligase HERC2; HECT and RLD domain containing E3 ubiquitin protein ligase 2; HECT domain and RCC1-like domain-containing protein 2; hect domain and RLD 2; HECT-type E3 ubiquitin transferase HERC2; HERC2; jdf2; KIAA0393; MRT38; p528; Probable E3 ubiquitin-protein ligase HERC2; SHEP1
Gene Symbols: HERC2
Molecular weight: 527,228 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB