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IL1B
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Belongs to the IL-1 family. Expressed in activated monocytes/macrophages (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Cytokine |
| Chromosomal Location of Human Ortholog: 2q14.1 |
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Cellular Component:
cytosol; extracellular exosome; extracellular region; extracellular space; lysosome
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Molecular Function:
cytokine activity; integrin binding; interleukin-1 receptor binding; protein binding; protein domain specific binding
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Biological Process:
activation of MAPK activity; apoptotic process; astrocyte activation; cell-cell signaling; cellular response to drug; cellular response to mechanical stimulus; cellular response to organic cyclic compound; cellular response to organic substance; cytokine-mediated signaling pathway; ectopic germ cell programmed cell death; embryo implantation; extrinsic apoptotic signaling pathway in absence of ligand; fever generation; hyaluronan biosynthetic process; immune response; inflammatory response; interleukin-1 beta production; interleukin-1-mediated signaling pathway; interleukin-6 production; lipopolysaccharide-mediated signaling pathway; MAPK cascade; monocyte aggregation; negative regulation of adiponectin secretion; negative regulation of cell proliferation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of glucose transmembrane transport; negative regulation of insulin receptor signaling pathway; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of synaptic transmission; positive regulation of angiogenesis; positive regulation of calcidiol 1-monooxygenase activity; positive regulation of cell adhesion molecule production; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemokine biosynthetic process; positive regulation of complement activation; positive regulation of DNA-binding transcription factor activity; positive regulation of epithelial to mesenchymal transition; positive regulation of fever generation; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of heterotypic cell-cell adhesion; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-6 secretion; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of lipid catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of mitotic nuclear division; positive regulation of monocyte chemotactic protein-1 production; positive regulation of myosin light chain kinase activity; positive regulation of neuroinflammatory response; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of p38MAPK cascade; positive regulation of phagocytosis; positive regulation of prostaglandin biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of protein export from nucleus; positive regulation of protein phosphorylation; positive regulation of RNA biosynthetic process; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell cytokine production; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein kinase B signaling; regulation of defense response to virus by host; regulation of ERK1 and ERK2 cascade; regulation of establishment of endothelial barrier; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of insulin secretion; regulation of neurogenesis; regulation of nitric-oxide synthase activity; regulation of signaling receptor activity; response to ATP; response to carbohydrate; response to interleukin-1; response to lipopolysaccharide; sequestering of triglyceride; signal transduction; smooth muscle adaptation
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Disease: Gastric Cancer, Hereditary Diffuse
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Reference #:
P01584
(UniProtKB)
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Alt. Names/Synonyms: Catabolin; IL-1; IL-1 beta; IL1-BETA; IL1B; IL1beta; IL1F2; interleukin 1 beta; interleukin 1, beta; interleukin 1beta; Interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
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Gene Symbols: IL1B
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Molecular weight:
30,748 Da
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Basal Isoelectric point:
4.7
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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