CYP1A1 A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Belongs to the cytochrome P450 family. Lung, lymphocytes and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Cofactor and Vitamin Metabolism - retinol; EC; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of human Ortholog: 15q24.1
Cellular Component:  endoplasmic reticulum membrane; intracellular membrane-bounded organelle; mitochondrial inner membrane
Molecular Function:  arachidonic acid monooxygenase activity; aromatase activity; demethylase activity; enzyme binding; estrogen 16-alpha-hydroxylase activity; estrogen 2-hydroxylase activity; flavonoid 3'-monooxygenase activity; heme binding; Hsp70 protein binding; Hsp90 protein binding; hydroperoxy icosatetraenoate dehydratase activity; iron ion binding; long-chain fatty acid omega-1 hydroxylase activity; long-chain fatty acid omega-hydroxylase activity; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on diphenols and related substances as donors; oxygen binding; protein binding; vitamin D 24-hydroxylase activity
Biological Process:  9-cis-retinoic acid biosynthetic process; aging; amine metabolic process; camera-type eye development; cell population proliferation; cellular response to copper ion; cellular response to organic cyclic compound; coumarin metabolic process; dibenzo-p-dioxin catabolic process; digestive tract development; DNA methylation; epoxygenase P450 pathway; estrogen metabolic process; ethylene metabolic process; fatty acid metabolic process; flavonoid metabolic process; hepatocyte differentiation; hydrogen peroxide biosynthetic process; insecticide metabolic process; lipid hydroxylation; long-chain fatty acid biosynthetic process; long-chain fatty acid metabolic process; maternal process involved in parturition; omega-hydroxylase P450 pathway; porphyrin-containing compound metabolic process; positive regulation of G1/S transition of mitotic cell cycle; response to antibiotic; response to arsenic-containing substance; response to food; response to herbicide; response to hyperoxia; response to hypoxia; response to immobilization stress; response to iron(III) ion; response to lipopolysaccharide; response to nematode; response to virus; response to vitamin A; response to wounding; retinol metabolic process; steroid biosynthetic process; steroid metabolic process; vitamin D metabolic process; xenobiotic metabolic process
Reference #:  P04798 (UniProtKB)
Alt. Names/Synonyms: AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CP1A1; CYP1; CYP1A1; CYPIA1; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; cytochrome P450 family 1 subfamily A member 1; Cytochrome P450 form 6; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; P1-450; P450-C; P450DX; xenobiotic monooxygenase
Gene Symbols: CYP1A1
Molecular weight: 58,165 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB