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CFLAR
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Belongs to the peptidase C14A family. Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle. 15 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis |
| Chromosomal Location of human Ortholog: 2q33.1 |
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Cellular Component:
CD95 death-inducing signaling complex; cytoplasm; cytosol; death-inducing signaling complex; ripoptosome
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Molecular Function:
cysteine-type endopeptidase activity involved in apoptotic process; death receptor binding; enzyme activator activity; protease binding; protein binding; protein-containing complex binding
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Biological Process:
apoptotic process; cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to nitric oxide; erythrocyte differentiation; keratinocyte differentiation; negative regulation of apoptotic process; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of hepatocyte apoptotic process; negative regulation of myoblast fusion; negative regulation of reactive oxygen species biosynthetic process; neuron differentiation; positive regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of extracellular matrix organization; positive regulation of glomerular mesangial cell proliferation; positive regulation of hepatocyte proliferation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; proteolysis; regulation of necroptotic process; regulation of skeletal muscle satellite cell proliferation; response to testosterone; skeletal muscle atrophy; skeletal muscle tissue development; skeletal muscle tissue regeneration; skeletal myofibril assembly; wound healing
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Reference #:
O15519
(UniProtKB)
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Alt. Names/Synonyms: c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8 and FADD like apoptosis regulator; CASP8 and FADD-like apoptosis regulator; CASP8 and FADD-like apoptosis regulator subunit p12; CASP8 and FADD-like apoptosis regulator subunit p43; CASP8AP1; Caspase homolog; Caspase-eight-related protein; Caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory protein; CFLAR; cFLIP; CLARP; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; testis secretory sperm-binding protein Li 233m; Usurpin; usurpin beta
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Gene Symbols: CFLAR
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Molecular weight:
55,344 Da
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Basal Isoelectric point:
8.19
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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Inhibition of Apoptosis
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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