AQP1
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Belongs to the MIP/aquaporin (TC 1.A.8) family. Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family |
Chromosomal Location of human Ortholog: 7p14.3 |
Cellular Component:
ankyrin-1 complex; apical part of cell; apical plasma membrane; axon; basal plasma membrane; basolateral plasma membrane; brush border; brush border membrane; cytoplasm; extracellular exosome; nuclear membrane; nucleus; plasma membrane; sarcolemma
|
Molecular Function:
ammonium transmembrane transporter activity; carbon dioxide transmembrane transporter activity; ephrin receptor binding; glycerol transmembrane transporter activity; identical protein binding; intracellular cGMP-activated cation channel activity; nitric oxide transmembrane transporter activity; potassium channel activity; potassium ion transmembrane transporter activity; protein binding; transmembrane transporter activity; water channel activity; water transmembrane transporter activity
|
Biological Process:
ammonium transmembrane transport; camera-type eye morphogenesis; carbon dioxide transmembrane transport; carbon dioxide transport; cell volume homeostasis; cellular homeostasis; cellular hyperosmotic response; cellular response to cAMP; cellular response to copper ion; cellular response to dexamethasone stimulus; cellular response to hydrogen peroxide; cellular response to hypoxia; cellular response to inorganic substance; cellular response to mechanical stimulus; cellular response to mercury ion; cellular response to nitric oxide; cellular response to retinoic acid; cellular response to salt stress; cellular response to UV; cerebrospinal fluid secretion; cGMP-mediated signaling; corticotropin secretion; defense response to Gram-negative bacterium; establishment of localization in cell; establishment or maintenance of actin cytoskeleton polarity; fibroblast migration; glomerular filtration; glycerol transmembrane transport; hyperosmotic response; intracellular water homeostasis; lateral ventricle development; lipid digestion; metanephric descending thin limb development; metanephric glomerulus vasculature development; metanephric proximal convoluted tubule segment 2 development; metanephric proximal straight tubule development; multicellular organismal-level water homeostasis; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; nitric oxide transport; odontogenesis; pancreatic juice secretion; positive regulation of angiogenesis; positive regulation of fibroblast migration; positive regulation of fibroblast proliferation; positive regulation of saliva secretion; potassium ion transmembrane transport; potassium ion transport; renal water absorption; renal water homeostasis; renal water transport; secretory granule organization; sensory perception of pain; transepithelial water transport; water transport; wound healing
|
Disease: Blood Group--colton
|
Reference #:
P29972
(UniProtKB)
|
Alt. Names/Synonyms: AQP-1; AQP-CHIP; AQP1; aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group); aquaporin 1 (Colton blood group); aquaporin 1, Colton blood group antigen; Aquaporin-1; Aquaporin-CHIP; channel-like integral membrane protein, 28-kDa; CHIP28; CO; Colton blood group; MGC26324; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule
|
Gene Symbols: AQP1
|
Molecular weight:
28,526 Da
|
Basal Isoelectric point:
6.95
Predict pI for various phosphorylation states
|