K8
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Belongs to the intermediate filament family. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cytoskeletal |
Chromosomal Location of human Ortholog: 12q13.13 |
Cellular Component:
apicolateral plasma membrane; cell-cell junction; costamere; cytoplasm; cytosol; dystrophin-associated glycoprotein complex; intermediate filament; intermediate filament cytoskeleton; keratin filament; nuclear matrix; nucleoplasm; sarcolemma; Z disc
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Molecular Function:
protein binding; protein-containing complex binding; scaffold protein binding
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Biological Process:
cell differentiation involved in embryonic placenta development; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway
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Disease: Cirrhosis, Familial
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Reference #:
P05787
(UniProtKB)
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Alt. Names/Synonyms: CARD2; CK-8; CK8; CYK8; cytokeratin 8; Cytokeratin-8; K2C8; K8; keratin 8; keratin 8, type II; Keratin, type II cytoskeletal 8; Keratin-8; KO; KRT8; Type-II keratin Kb8
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Gene Symbols: KRT8
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Molecular weight:
53,704 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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