K8 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  apicolateral plasma membrane; cell-cell junction; costamere; cytoplasm; cytosol; dystrophin-associated glycoprotein complex; intermediate filament; intermediate filament cytoskeleton; keratin filament; nuclear matrix; nucleoplasm; sarcolemma; Z disc
Molecular Function:  protein binding; protein-containing complex binding; scaffold protein binding; structural molecule activity
Biological Process:  cell differentiation involved in embryonic placenta development; cornification; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; keratinization; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway; viral process
Disease: Cirrhosis, Familial
Reference #:  P05787 (UniProtKB)
Alt. Names/Synonyms: CARD2; CK-8; CK8; CYK8; cytokeratin 8; Cytokeratin-8; K2C8; K8; keratin 8; Keratin, type II cytoskeletal 8; Keratin-8; KO; KRT8; Type-II keratin Kb8
Gene Symbols: KRT8
Molecular weight: 53,704 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene