K8 Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Belongs to the intermediate filament family. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  apicolateral plasma membrane; cell-cell junction; costamere; cytoplasm; cytosol; dystrophin-associated glycoprotein complex; intermediate filament; intermediate filament cytoskeleton; keratin filament; nuclear matrix; nucleoplasm; sarcolemma; Z disc
Molecular Function:  protein binding; protein-containing complex binding; scaffold protein binding; structural molecule activity
Biological Process:  cell differentiation involved in embryonic placenta development; cornification; extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; keratinization; response to hydrostatic pressure; response to other organism; sarcomere organization; tumor necrosis factor-mediated signaling pathway; viral process
Disease: Cirrhosis, Familial
Reference #:  P05787 (UniProtKB)
Alt. Names/Synonyms: CARD2; CK-8; CK8; CYK8; cytokeratin 8; Cytokeratin-8; K2C8; K8; keratin 8; Keratin, type II cytoskeletal 8; Keratin-8; KO; KRT8; Type-II keratin Kb8
Gene Symbols: KRT8
Molecular weight: 53,704 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene