PTPRO Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 12p12.3|12p13-p12
Cellular Component:  apical plasma membrane; axon; dendritic spine; GABA-ergic synapse; glutamatergic synapse; growth cone; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic density membrane; lamellipodium; lateral plasma membrane; neuron projection; plasma membrane
Molecular Function:  phosphatase activity; protein binding; protein homodimerization activity; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; Wnt-protein binding
Biological Process:  axon guidance; cell morphogenesis; glomerular visceral epithelial cell differentiation; glomerulus development; lamellipodium assembly; monocyte chemotaxis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell-substrate adhesion; negative regulation of glomerular filtration; negative regulation of neuron projection development; negative regulation of retinal ganglion cell axon guidance; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of glomerular filtration; regulation of synapse organization; slit diaphragm assembly
Disease: Nephrotic Syndrome, Type 6
Reference #:  Q16827 (UniProtKB)
Alt. Names/Synonyms: GLEPP1; Glomerular epithelial protein 1; glomerular epithelial protein-1; osteoclastic transmembrane protein-tyrosine phosphatase; phosphotyrosine phosphatase U2; protein tyrosine phosphatase PTP-U2; Protein tyrosine phosphatase U2; protein tyrosine phosphatase, receptor type, O; PTP-oc; PTP-U2; PTPase U2; PTPRO; PTPROt; PTPU2; R-PTP-O; receptor-type protein tyrosine phosphatase O; Receptor-type tyrosine-protein phosphatase O
Gene Symbols: PTPRO
Molecular weight: 138,344 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein