K18 Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Belongs to the intermediate filament family. Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Nucleolus
Chromosomal Location of mouse Ortholog: 15 F2|15 57.22 cM
Cellular Component:  cell periphery; centriolar satellite; cytoplasm; cytoskeleton; cytosol; external side of plasma membrane; extracellular space; intermediate filament; keratin filament; microtubule organizing center; nucleus; protein-containing complex
Molecular Function:  protein binding; scaffold protein binding; structural molecule activity
Biological Process:  extrinsic apoptotic signaling pathway; Golgi to plasma membrane protein transport; hepatocyte apoptotic process; intermediate filament cytoskeleton organization; negative regulation of apoptotic process; tumor necrosis factor-mediated signaling pathway
Reference #:  P05784 (UniProtKB)
Alt. Names/Synonyms: CK-18; CK18; Cytokeratin endo B; Cytokeratin-18; Endo B; K18; K1C18; keratin 18; keratin complex 1, acidic, gene 18; Keratin D; Keratin, type I cytoskeletal 18; Keratin-18; Kerd; Krt1-1; Krt1-18; Krt18
Gene Symbols: Krt18
Molecular weight: 47,538 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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K18

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein