SGK3 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); SGK family
Chromosomal Location of Human Ortholog: 1 A2|1 2.08 cM
Cellular Component:  cytoplasmic vesicle; endosome
Molecular Function:  ATP binding; kinase activity; nucleotide binding; phosphatidylinositol binding; potassium channel regulator activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  intracellular signal transduction; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; peptidyl-serine phosphorylation; phosphorylation
Reference #:  Q9ERE3 (UniProtKB)
Alt. Names/Synonyms: 2510015P22Rik; A330005P07Rik; Cisk; Cytokine-independent survival kinase; fy; fz; serine/threonine protein kinase CISK; Serine/threonine-protein kinase Sgk3; serum/glucocorticoid regulated kinase 3; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; Sgk3; Sgkl
Gene Symbols: Sgk3
Molecular weight: 57,145 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SGK3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene