CIITA Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 16|16 A1
Cellular Component:  cell surface; nucleus; PML body
Molecular Function:  activating transcription factor binding; ATP binding; GTP binding; kinase activity; nucleotide binding; protein C-terminus binding; protein-containing complex binding; transcription regulatory region DNA binding; transferase activity; transferase activity, transferring acyl groups
Biological Process:  inflammatory response; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; phosphorylation; positive regulation of MHC class I biosynthetic process; positive regulation of MHC class II biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; response to antibiotic; response to interferon-gamma
Reference #:  P79621 (UniProtKB)
Alt. Names/Synonyms: C2t; C2ta; CIITA; class II transactivator; EG669998; Gm9475; MGC130299; MHC class II transactivator; Mhc2ta
Gene Symbols: Ciita
Molecular weight: 127,528 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene