EphA8 Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of rat Ortholog: 5q36
Cellular Component:  early endosome membrane; integral component of plasma membrane; neuron projection; receptor complex
Molecular Function:  ATP binding; GPI-linked ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  axon guidance; cell adhesion; cellular response to follicle-stimulating hormone stimulus; ephrin receptor signaling pathway; neuron projection development; neuron remodeling; peptidyl-tyrosine phosphorylation; positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; protein autophosphorylation; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; substrate-dependent cell migration; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  XP_342953 (RefSeq)
Alt. Names/Synonyms: Eek; eph and elk-related kinase; Eph receptor A8; EPH- and ELK-related kinase; Epha8; ephrin receptor EphA8; Ephrin type-A receptor 8; Tyrosine-protein kinase receptor EEK
Gene Symbols: Epha8
Molecular weight: 108,280 Da
Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene