PPME1 Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. Belongs to the AB hydrolase superfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of human Ortholog: 11q13.4
Cellular Component:  nucleoplasm
Molecular Function:  lncRNA binding; protein binding; protein C-terminal methylesterase activity; protein kinase binding; protein methylesterase activity; protein phosphatase 2A binding; protein phosphatase binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity
Biological Process:  G2/M transition of mitotic cell cycle; negative regulation of catalytic activity; protein demethylation; protein phosphorylation
Reference #:  Q9Y570 (UniProtKB)
Alt. Names/Synonyms: ABDH19; FLJ22226; PME-1; PME1; PPME1; Protein phosphatase methylesterase 1; protein phosphatase methylesterase-1; testicular secretory protein Li 39
Gene Symbols: PPME1
Molecular weight: 42,315 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene