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PPME1
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. Belongs to the AB hydrolase superfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.1.89; Hydrolase; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit |
| Chromosomal Location of human Ortholog: 11q13.4 |
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Cellular Component:
nucleoplasm
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Molecular Function:
lncRNA binding; protein binding; protein C-terminal methylesterase activity; protein kinase binding; protein methylesterase activity; protein phosphatase 2A binding; protein phosphatase binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity
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Biological Process:
G2/M transition of mitotic cell cycle; negative regulation of catalytic activity; protein demethylation; protein phosphorylation
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Reference #:
Q9Y570
(UniProtKB)
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Alt. Names/Synonyms: ABDH19; FLJ22226; PME-1; PME1; PPME1; Protein phosphatase methylesterase 1; protein phosphatase methylesterase-1; testicular secretory protein Li 39
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Gene Symbols: PPME1
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Molecular weight:
42,315 Da
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Basal Isoelectric point:
5.67
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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