MAML1 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Belongs to the mastermind family. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component:  intracellular membrane-bounded organelle; MAML1-RBP-Jkappa- ICN1 complex; nuclear speck; nucleoplasm; nucleus
Molecular Function:  peptide antigen binding; protein binding; protein kinase binding; transcription coactivator activity
Biological Process:  atrioventricular node cell development; atrioventricular node development; myoblast differentiation; Notch signaling pathway; positive regulation of myotube differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target; protein phosphorylation; transcription initiation from RNA polymerase II promoter
Reference #:  Q92585 (UniProtKB)
Alt. Names/Synonyms: FLJ53540; KIAA0200; Mam-1; Mam1; MAML1; mastermind homolog; mastermind-like 1 (Drosophila); Mastermind-like protein 1
Gene Symbols: MAML1
Molecular weight: 108,054 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene