CETN2 Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Belongs to the centrin family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Cell cycle regulation; DNA repair, damage
Chromosomal Location of mouse Ortholog: X A7.3|X 37.29 cM
Cellular Component:  9+2 motile cilium; apical part of cell; centriole; centrosome; ciliary basal body; cilium; cytoplasm; cytoskeleton; nuclear pore; nuclear pore nuclear basket; nucleus; photoreceptor connecting cilium; transcription export complex 2; XPC complex
Molecular Function:  calcium ion binding; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein binding; metal ion binding; microtubule binding
Biological Process:  cell cycle; cell division; centriole replication; DNA damage response; DNA repair; mitotic cell cycle; mRNA transport; nucleotide-excision repair; protein transport; regulation of cytokinesis; spermatogenesis
Reference #:  Q9R1K9 (UniProtKB)
Alt. Names/Synonyms: 1110034A02Rik; AI326150; Calt; caltractin; Caltractin isoform 1; caltractin, 20 kDa calcium binding protein; centrin 2; Centrin-2; Cetn2; OTTMUSP00000019428
Gene Symbols: Cetn2
Molecular weight: 19,797 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein