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EFNA4
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. Belongs to the ephrin family. Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor |
| Chromosomal Location of mouse Ortholog: 3 F1|3 39.07 cM |
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Cellular Component:
membrane; plasma membrane
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Molecular Function:
ephrin receptor binding
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Biological Process:
axon guidance; ephrin receptor signaling pathway
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Reference #:
O08542
(UniProtKB)
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Alt. Names/Synonyms: EFL-; EFL-4; EFNA4; EPH-related receptor tyrosine kinase ligand 4; ephrin A4; Ephrin-A4; Epl4; Eplg4; LERK; LERK-4; Lerk4
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Gene Symbols: Efna4
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Molecular weight:
22,861 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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| Select Structure to View Below |
EFNA4
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