AQP3 Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  basolateral plasma membrane; cell-cell junction; cytoplasm; integral component of membrane; nucleus; plasma membrane
Molecular Function:  glycerol channel activity; water channel activity
Biological Process:  cellular response to hypoxia; cellular response to oxygen-glucose deprivation; glycerol transport; odontogenesis; positive regulation of immune system process; regulation of keratinocyte differentiation; renal water absorption; renal water homeostasis; response to calcium ion; response to retinoic acid; response to vitamin D; urea transmembrane transport; water transport
Disease: Gil Blood Group
Reference #:  Q92482 (UniProtKB)
Alt. Names/Synonyms: AQP-3; AQP3; Aquaglyceroporin-3; aquaporin 3 (GIL blood group); aquaporin 3 (Gill blood group); Aquaporin-3; GIL
Gene Symbols: AQP3
Molecular weight: 31,544 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein