RAMP1 Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Belongs to the RAMP family. Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, GPCR
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  amylin receptor complex 1; cell; cell surface; CGRP receptor complex; extracellular space; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function:  amylin receptor activity; calcitonin gene-related peptide binding; calcitonin gene-related peptide receptor activity; protein binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; angiogenesis; calcitonin gene-related peptide receptor signaling pathway; calcium ion transport; G protein-coupled receptor signaling pathway; intracellular protein transport; positive regulation of protein glycosylation; protein localization to plasma membrane; protein transport; receptor internalization; regulation of G protein-coupled receptor signaling pathway
Reference #:  O60894 (UniProtKB)
Alt. Names/Synonyms: calcitonin receptor-like receptor activity modifying protein 1; Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1; RAMP1; receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor activity modifying protein 1; Receptor activity-modifying protein 1
Gene Symbols: RAMP1
Molecular weight: 16,988 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein