IL21
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 4q27 |
Cellular Component:
extracellular region; extracellular space
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Molecular Function:
cytokine activity; cytokine receptor binding; interleukin-2 receptor binding; protein binding
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Biological Process:
cell maturation; cellular response to virus; defense response to virus; germinal center B cell differentiation; positive regulation of B cell proliferation; positive regulation of cell population proliferation; positive regulation of cytokine production; positive regulation of immunoglobulin production; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tissue remodeling; positive regulation of type II interferon production; positive regulation of tyrosine phosphorylation of STAT protein; signal transduction; T follicular helper cell differentiation; tyrosine phosphorylation of STAT protein
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Disease: Immunodeficiency, Common Variable, 11
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Reference #:
Q9HBE4
(UniProtKB)
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Alt. Names/Synonyms: CVID11; IL-21; IL21; interleukin 21; Interleukin-21; Za11
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Gene Symbols: IL21
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Molecular weight:
18,653 Da
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Basal Isoelectric point:
9.54
Predict pI for various phosphorylation states
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