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ULBP2
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Belongs to the MHC class I family. Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, GPI anchor |
| Chromosomal Location of human Ortholog: 6q25.1 |
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Cellular Component:
cell surface; endoplasmic reticulum; external side of plasma membrane; extracellular region; extracellular space; intracellular membrane-bounded organelle; plasma membrane
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Molecular Function:
natural killer cell lectin-like receptor binding; protein binding
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Biological Process:
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; immune response; natural killer cell activation; natural killer cell mediated cytotoxicity; positive regulation of T cell mediated cytotoxicity
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Reference #:
Q9BZM5
(UniProtKB)
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Alt. Names/Synonyms: ALCAN-alpha; N2DL-2; N2DL2; NKG2D ligand 2; NKG2DL2; RAET1H; RAET1L; Retinoic acid early transcript 1H; retinoic acid early transcript 1L; UL16 binding protein 2; UL16-binding protein 2; ULBP2
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Gene Symbols: ULBP2
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Molecular weight:
27,368 Da
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Basal Isoelectric point:
6.93
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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