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WNT6
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. Belongs to the Wnt family. Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Extracellular matrix; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 2q35 |
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Cellular Component:
cell surface; endocytic vesicle membrane; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space; Golgi lumen; plasma membrane
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Molecular Function:
cytokine activity; frizzled binding
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Biological Process:
axis specification; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; cell fate commitment; cellular response to retinoic acid; cornea development in camera-type eye; epithelial-mesenchymal cell signaling; nephron tubule formation; neuron differentiation; odontogenesis of dentin-containing tooth; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of tooth mineralization
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Reference #:
Q9Y6F9
(UniProtKB)
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Alt. Names/Synonyms: Protein Wnt-6; wingless-type MMTV integration site family, member 6; Wnt family member 6; WNT6
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Gene Symbols: WNT6
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Molecular weight:
39,721 Da
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Basal Isoelectric point:
9.22
Predict pI for various phosphorylation states
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