TNFSF14 Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production. Belongs to the tumor necrosis factor family. Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Inhibitor; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cytoplasm; extracellular space; integral component of membrane; plasma membrane
Molecular Function:  cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokine activity; protein binding; signaling receptor binding; tumor necrosis factor receptor binding
Biological Process:  apoptotic process; cellular response to mechanical stimulus; immune response; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of myoblast differentiation; positive regulation of myoblast fusion; positive regulation of NIK/NF-kappaB signaling; positive regulation of T cell chemotaxis; regulation of signaling receptor activity; signal transduction; T cell activation; T cell costimulation; T cell homeostasis; T cell proliferation; tumor necrosis factor-mediated signaling pathway
Reference #:  O43557 (UniProtKB)
Alt. Names/Synonyms: CD258; Herpes virus entry mediator ligand; Herpesvirus entry mediator ligand; HVEM-L; HVEML; LIGHT; LTg; TNF superfamily member 14; TNF14; TNFSF14; TR2; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; Tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form; tumor necrosis factor superfamily member 14
Gene Symbols: TNFSF14
Molecular weight: 26,350 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept