FGF21
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family. Note: This description may include information from UniProtKB.
|
Protein type: Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 19q13.33 |
Cellular Component:
cytoplasm; extracellular region; extracellular space
|
Molecular Function:
fibroblast growth factor receptor binding; growth factor activity; protein binding
|
Biological Process:
animal organ morphogenesis; cell differentiation; cell-cell signaling; cellular response to glucagon stimulus; cellular response to glucose stimulus; cellular response to low-density lipoprotein particle stimulus; cellular response to xenobiotic stimulus; endoplasmic reticulum unfolded protein response; endothelial cell apoptotic process; fibroblast growth factor receptor signaling pathway; negative regulation of endothelial cell apoptotic process; negative regulation of neuron death; positive regulation of cell population proliferation; positive regulation of cold-induced thermogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose import; positive regulation of low-density lipoprotein receptor activity; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; positive regulation of protein phosphorylation; positive regulation of triglyceride catabolic process; regulation of cell migration; regulation of low-density lipoprotein particle clearance; response to activity; response to methionine; response to nutrient levels; signal transduction
|
Reference #:
Q9NSA1
(UniProtKB)
|
Alt. Names/Synonyms: FGF-21; FGF21; Fibroblast growth factor 21
|
Gene Symbols: FGF21
|
Molecular weight:
22,300 Da
|
Basal Isoelectric point:
5.01
Predict pI for various phosphorylation states
|