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IL23A
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Belongs to the IL-6 superfamily. Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Cytokine; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 12q13.3 |
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Cellular Component:
endoplasmic reticulum lumen; extracellular region; interleukin-23 complex
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Molecular Function:
cytokine activity; interleukin-23 receptor binding; protein binding
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Biological Process:
defense response to Gram-negative bacterium; defense response to virus; inflammatory response; innate immune response; negative regulation of interleukin-10 production; positive regulation of activated T cell proliferation; positive regulation of activation of Janus kinase activity; positive regulation of defense response to virus by host; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of inflammatory response; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell activation; positive regulation of natural killer cell proliferation; positive regulation of neutrophil chemotaxis; positive regulation of NIK/NF-kappaB signaling; positive regulation of NK T cell activation; positive regulation of NK T cell proliferation; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of T-helper 1 type immune response; positive regulation of T-helper 17 cell lineage commitment; positive regulation of T-helper 17 type immune response; positive regulation of tissue remodeling; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; positive regulation of tyrosine phosphorylation of STAT protein; regulation of tyrosine phosphorylation of STAT protein; signal transduction; T cell proliferation; tissue remodeling
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Reference #:
Q9NPF7
(UniProtKB)
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Alt. Names/Synonyms: IL-23; IL-23 subunit alpha; IL-23-A; IL-23A; IL-23p19; IL23A; IL23P19; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; P19; SGRF
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Gene Symbols: IL23A
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Molecular weight:
20,730 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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