RAMP3 Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family. Strongly expressed in lung, breast, immune system and fetal tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 7p13
Cellular Component:  adrenomedullin receptor complex; amylin receptor complex 3; cell; cell surface; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function:  adrenomedullin receptor activity; amyloid-beta binding; protein binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adrenomedullin receptor signaling pathway; amylin receptor signaling pathway; calcium ion transport; cellular response to estradiol stimulus; cross-receptor inhibition within G protein-coupled receptor heterodimer; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway involved in heart process; intracellular protein transport; positive regulation of calcium ion import across plasma membrane; positive regulation of cell death; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase A signaling; positive regulation of protein kinase B signaling; positive regulation of protein localization to plasma membrane; positive regulation of receptor recycling; protein localization to plasma membrane; protein transport; receptor internalization; response to amyloid-beta
Reference #:  O60896 (UniProtKB)
Alt. Names/Synonyms: calcitonin receptor-like receptor activity modifying protein 3; Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3; RAMP3; receptor (calcitonin) activity modifying protein 3; receptor (G protein-coupled) activity modifying protein 3; receptor activity modifying protein 3; Receptor activity-modifying protein 3
Gene Symbols: RAMP3
Molecular weight: 16,518 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below

RAMP3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein