CENPA a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component:  chromosome, centromeric region; condensed chromosome inner kinetochore; condensed nuclear chromosome kinetochore; condensed nuclear chromosome, centromeric region; cytosol; nuclear nucleosome; nuclear pericentric heterochromatin; nucleoplasm; nucleus
Molecular Function:  chromatin binding; protein binding; protein heterodimerization activity
Biological Process:  CENP-A containing nucleosome assembly; establishment of mitotic spindle orientation; kinetochore assembly; mitotic cytokinesis; protein localization to chromosome, centromeric region; viral process
Reference #:  P49450 (UniProtKB)
Alt. Names/Synonyms: CENP-A; CENPA; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; Histone H3-like centromeric protein A
Gene Symbols: CENPA
Molecular weight: 15,991 Da
Basal Isoelectric point: 11.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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