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USF1
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 1q23.3 |
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Cellular Component:
chromatin; Golgi apparatus; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
bHLH transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; histone deacetylase binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
carbon catabolite regulation of transcription; cellular response to insulin stimulus; glucose homeostasis; late viral transcription; lipid homeostasis; negative regulation of fibrinolysis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; response to UV
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Disease: Hyperlipidemia, Combined, 1
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Reference #:
P22415
(UniProtKB)
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Alt. Names/Synonyms: BHLHB11; Class B basic helix-loop-helix protein 11; FCHL; FCHL1; HYPLIP1; Major late transcription factor 1; MLTF; MLTFI; UEF; Upstream stimulatory factor 1; upstream transcription factor 1; USF; USF1
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Gene Symbols: USF1
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Molecular weight:
33,538 Da
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Basal Isoelectric point:
5.36
Predict pI for various phosphorylation states
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