ELF4 Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Belongs to the ETS family. Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of human Ortholog: Xq26.1
Cellular Component:  nuclear body; nucleoplasm; PML body
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  innate immune response; natural killer cell proliferation; NK T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated
Reference #:  Q99607 (UniProtKB)
Alt. Names/Synonyms: E74 like ETS transcription factor 4; E74-like factor 4; E74-like factor 4 (ets domain transcription factor); ELF4; ELFR; ETS-related transcription factor Elf-4; MEF; Myeloid Elf-1-like factor
Gene Symbols: ELF4
Molecular weight: 70,730 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
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ELF4

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein