CDK5 a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK5 subfamily; CDK5 subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5 A3|5 11.73 cM
Cellular Component:  axon; cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; filopodium; glutamatergic synapse; growth cone; lamellipodium; membrane; neuromuscular junction; neuron projection; neuronal cell body; nucleus; plasma membrane; postsynapse; postsynaptic density; postsynaptic membrane; protein kinase 5 complex; Schaffer collateral - CA1 synapse; synapse
Molecular Function:  acetylcholine receptor activator activity; ATP binding; cyclin-dependent protein serine/threonine kinase activity; cytoskeletal protein binding; ephrin receptor binding; ErbB-2 class receptor binding; ErbB-3 class receptor binding; Hsp90 protein binding; kinase activity; nucleotide binding; p53 binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; tau-protein kinase activity; transferase activity; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
Biological Process:  apoptotic process; associative learning; axonogenesis; behavioral response to cocaine; calcium ion import; cell cycle; cell division; cell migration; cell-matrix adhesion; cellular response to amyloid-beta; central nervous system neuron development; cerebellar cortex development; cerebellar cortex formation; cerebellum development; cerebral cortex development; corpus callosum development; cortical actin cytoskeleton organization; dendrite morphogenesis; excitatory postsynaptic potential; exocytosis; forebrain development; hippocampus development; histone phosphorylation; intracellular protein transport; layer formation in cerebral cortex; mitochondrion organization; motor neuron axon guidance; negative regulation of axon extension; negative regulation of cell cycle; negative regulation of neuron death; negative regulation of protein export from nucleus; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of synaptic plasticity; negative regulation of transcription, DNA-templated; nervous system development; neuron apoptotic process; neuron differentiation; neuron migration; neuron projection development; neuron projection morphogenesis; nucleocytoplasmic transport; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of calcium ion-dependent exocytosis; positive regulation of glial cell apoptotic process; positive regulation of neuron apoptotic process; positive regulation of neuron death; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; protein autophosphorylation; protein localization to synapse; protein phosphorylation; receptor catabolic process; receptor clustering; regulated exocytosis; regulation of cell migration; regulation of dendritic spine morphogenesis; regulation of postsynaptic membrane potential; regulation of protein localization to plasma membrane; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; response to cocaine; response to wounding; rhythmic process; Schwann cell development; sensory perception of pain; serine phosphorylation of STAT protein; skeletal muscle tissue development; synapse assembly; synapse pruning; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; synaptic vesicle endocytosis; synaptic vesicle transport; telencephalon development; visual learning
Reference #:  P49615 (UniProtKB)
Alt. Names/Synonyms: AW048668; Cdk5; Cdkn5; Cell division protein kinase 5; CR6 protein kinase; Crk; CRK6; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Symbols: Cdk5
Molecular weight: 33,288 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene