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MARCH3
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 18 D3|18 |
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Cellular Component:
cytoplasmic vesicle; endosome; intracellular membrane-bounded organelle; lysosome; membrane
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Molecular Function:
metal ion binding; transferase activity; ubiquitin-protein transferase activity; zinc ion binding
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Biological Process:
endocytosis; protein ubiquitination
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Reference #:
Q8BRX9
(UniProtKB)
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Alt. Names/Synonyms: 6330411I15Rik; A530081L18Rik; AI843639; E3 ubiquitin-protein ligase MARCH3; E3 ubiquitin-protein ligase MARCHF3; Marc; MARCH-III; March3; Marchf3; MARH3; membrane associated ring-CH-type finger 3; membrane-associated ring finger (C3HC4) 3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; MGC130167; MGC130168; OTTMUSP00000017975; RING-type E3 ubiquitin transferase MARCH3; RING-type E3 ubiquitin transferase MARCHF3
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Gene Symbols: Marchf3
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Molecular weight:
24,491 Da
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Basal Isoelectric point:
8
Predict pI for various phosphorylation states
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