CDC25B Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. Belongs to the MPI phosphatase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Protein phosphatase, dual-specificity
Chromosomal Location of mouse Ortholog: 2 F1|2 63.29 cM
Cellular Component:  centrosome; cytoplasm; cytoskeleton; nucleus; spindle pole
Molecular Function:  hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity
Biological Process:  cell cycle; cell division; female meiosis I; G2/M transition of mitotic cell cycle; mitotic cell cycle; oocyte maturation; positive regulation of cell cycle G2/M phase transition; positive regulation of cytokinesis; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; positive regulation of mitotic cell cycle; positive regulation of protein kinase activity; protein dephosphorylation; protein phosphorylation
Reference #:  P30306 (UniProtKB)
Alt. Names/Synonyms: AI604853; Cdc25b; Cdc25m2; cell division cycle 25 homolog B (S. pombe); cell division cycle 25B; Dual specificity phosphatase Cdc25B; M-phase inducer phosphatase 2; MPIP2; OTTMUSP00000017157
Gene Symbols: Cdc25b
Molecular weight: 65,490 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDC25B

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA