CDK1 a protein kinase of the CDK family. Catalytic subunit of the conserved protein complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions. Mitotic cyclins stably associate with this protein and function as regulatory subunits. Its activity is controlled by cyclin availability and phosphorylation through the cell cycle. Activated in many cancers including colon, liver and breast. The T isoform, which lacks a regulatory region, is expressed in breast cancer. Inhibition in cancer cells may drive cells into apoptosis. May also drive cell migration. Inhibitors: BMS-265246, BMS-265246-01. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 10 B5.3|10 36.07 cM
Cellular Component:  centrosome; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; midbody; mitochondrion; mitotic spindle; nucleus; spindle microtubule
Molecular Function:  ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; histone kinase activity; Hsp70 protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; transferase activity
Biological Process:  animal organ regeneration; apoptotic process; cell aging; cell cycle; cell division; cell proliferation; chromosome condensation; Golgi disassembly; mitotic cell cycle phase transition; mitotic G2 DNA damage checkpoint; negative regulation of apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; positive regulation of protein localization to nucleus; protein localization to kinetochore; protein phosphorylation; protein-containing complex assembly; regulation of circadian rhythm; response to ethanol; response to organonitrogen compound
Reference #:  P11440 (UniProtKB)
Alt. Names/Synonyms: Cdc2; Cdc2a; CDK1; Cdkn1; cell cycle p34 CDC2 kinase protein; Cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle control protein 2a; Cell division protein kinase 1; Cyclin-dependent kinase 1; p34 protein kinase; p34<CDC2; p34<CDC2>
Gene Symbols: Cdk1
Molecular weight: 34,107 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling  |  G2/M DNA Damage Checkpoint  |  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDK1

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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene