FALZ
Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. Belongs to the PBTF family. Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Transcription factor |
Chromosomal Location of mouse Ortholog: 11|11 E1 |
Cellular Component:
ATPase complex; cell body; chromatin; dendrite; nucleoplasm; nucleus; NURF complex; perinuclear region of cytoplasm
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Molecular Function:
ATP-dependent activity, acting on DNA; methylated histone binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding
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Biological Process:
anterior/posterior pattern specification; brain development; chromatin remodeling; embryonic placenta development; endoderm development; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
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Reference #:
E9Q6A7
(UniProtKB)
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Alt. Names/Synonyms: 9430093H17Rik; Bptf; Bptf protein; Bromodomain PHD finger transcription factor; Falz; fetal Alzheimer antigen; MGC54978; nucleosome-remodeling factor subunit BPTF
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Gene Symbols: Bptf
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Molecular weight:
321,598 Da
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Basal Isoelectric point:
7.58
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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