SHANK3
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. Expressed in the cerebral cortex and the cerebellum. 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of mouse Ortholog: 15|15 E3 |
Cellular Component:
cell projection; ciliary membrane; cytoplasm; dendritic spine; excitatory synapse; glutamatergic synapse; neuron projection; neuron spine; plasma membrane; postsynaptic density; postsynaptic density, intracellular component; postsynaptic membrane; synapse
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Molecular Function:
actin binding; G protein-coupled receptor binding; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein self-association; protein-containing complex binding; scaffold protein binding; SH3 domain binding; structural constituent of postsynaptic density; synaptic receptor adaptor activity; zinc ion binding
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Biological Process:
adult behavior; AMPA glutamate receptor clustering; associative learning; brain morphogenesis; dendritic spine morphogenesis; embryonic epithelial tube formation; exploration behavior; gene expression; glial cell proliferation; guanylate kinase-associated protein clustering; learning; learning or memory; locomotion; locomotory behavior; locomotory exploration behavior; long-term synaptic depression; long-term synaptic potentiation; MAPK cascade; memory; modulation of chemical synaptic transmission; negative regulation of actin filament bundle assembly; negative regulation of cell volume; neural precursor cell proliferation; neuromuscular process controlling balance; NMDA glutamate receptor clustering; positive regulation of AMPA receptor activity; positive regulation of dendritic spine development; positive regulation of excitatory postsynaptic potential; positive regulation of glutamate receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of long-term synaptic potentiation; positive regulation of synapse structural plasticity; positive regulation of synaptic transmission, glutamatergic; postsynaptic density assembly; regulation of AMPA glutamate receptor clustering; regulation of behavioral fear response; regulation of dendritic spine morphogenesis; regulation of grooming behavior; regulation of long-term synaptic depression; regulation of long-term synaptic potentiation; regulation of postsynapse organization; regulation of synaptic plasticity; response to interleukin-17; social behavior; striatal medium spiny neuron differentiation; synapse assembly; vocal learning; vocalization behavior
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Reference #:
Q4ACU6
(UniProtKB)
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Alt. Names/Synonyms: AI841104; Kiaa1650; Proline-rich synapse-associated protein 2; ProSAP2; SH3 and multiple ankyrin repeat domains 3; SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3; SHAN3; Shank3; Shank3b; SPANK-2
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Gene Symbols: Shank3
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Molecular weight:
185,397 Da
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Basal Isoelectric point:
8.99
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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