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MEK2
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family |
| Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM |
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Cellular Component:
cell cortex; cell-cell junction; cytoplasm; cytoplasmic side of plasma membrane; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm
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Molecular Function:
ATP binding; kinase activity; MAP kinase kinase activity; metal ion binding; molecular adaptor activity; nucleotide binding; PDZ domain binding; protein binding; protein kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity
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Biological Process:
activation of MAPK activity; activation of protein kinase activity; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; lung morphogenesis; negative regulation of gene expression; peptidyl-serine autophosphorylation; phosphorylation; positive regulation of axonogenesis; positive regulation of cell motility; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of protein serine/threonine kinase activity; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade; thymus development; thyroid gland development; trachea formation
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Reference #:
Q63932
(UniProtKB)
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Alt. Names/Synonyms: AA589381; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; Map2k2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; Mek2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; MK2; Mkk2; MP2K2; OTTMUSP00000018442; Prkm; Prkmk2; protein kinase, mitogen activated, kinase 2, p45
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Gene Symbols: Map2k2
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Molecular weight:
44,402 Da
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Basal Isoelectric point:
6.58
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Angiogenesis
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B Cell Receptor Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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IL6 Signaling
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Insulin Receptor Signaling
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T Cell Receptor Signaling
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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