MEK2 Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM
Cellular Component:  cell cortex; cell-cell junction; cytoplasm; cytoplasmic side of plasma membrane; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; late endosome; membrane; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase activity; metal ion binding; molecular adaptor activity; nucleotide binding; PDZ domain binding; protein binding; protein kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding; transferase activity
Biological Process:  activation of MAPK activity; activation of protein kinase activity; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; heart development; lung morphogenesis; negative regulation of gene expression; peptidyl-serine autophosphorylation; phosphorylation; positive regulation of axonogenesis; positive regulation of cell motility; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of protein serine/threonine kinase activity; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade; thymus development; thyroid gland development; trachea formation
Reference #:  Q63932 (UniProtKB)
Alt. Names/Synonyms: AA589381; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; Map2k2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; Mek2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; MK2; Mkk2; MP2K2; OTTMUSP00000018442; Prkm; Prkmk2; protein kinase, mitogen activated, kinase 2, p45
Gene Symbols: Map2k2
Molecular weight: 44,402 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene