NDN Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 15q11.2
Cellular Component:  cell projection; centrosome; cytosol; nucleoplasm; nucleus; perikaryon; protein-containing complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; gamma-tubulin binding; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process:  axon extension; axonal fasciculation; central nervous system development; genomic imprinting; glial cell migration; multicellular organismal-level homeostasis; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; neuron migration; neurotrophin TRK receptor signaling pathway; positive regulation of protein deacetylation; positive regulation of transcription by RNA polymerase II; post-embryonic development; respiratory system process; sensory perception of pain
Disease: Prader-willi Syndrome
Reference #:  Q99608 (UniProtKB)
Alt. Names/Synonyms: HsT16328; NDN; NECD; Necdin; necdin homolog; necdin homolog (mouse); necdin, MAGE family member; necdin, melanoma antigen (MAGE) family member; necdin-like protein; Prader-Willi syndrome chromosome region; PWCR
Gene Symbols: NDN
Molecular weight: 36,086 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below

NDN
Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein