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ITGB2
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Belongs to the integrin beta chain family. Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980). Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM |
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Cellular Component:
cell surface; focal adhesion; integral component of membrane; integrin alphaL-beta2 complex; integrin alphaM-beta2 complex; integrin complex; membrane; membrane raft; plasma membrane; plasma membrane raft; receptor complex
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Molecular Function:
amyloid-beta binding; cell adhesion molecule binding; complement component C3b binding; heat shock protein binding; ICAM-3 receptor activity; integrin binding; metal ion binding; protein binding; protein heterodimerization activity; protein kinase binding; protein-containing complex binding; signaling receptor activity
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Biological Process:
activated T cell proliferation; amyloid-beta clearance; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion; cell-matrix adhesion; cellular extravasation; cellular response to low-density lipoprotein particle stimulus; endothelial cell migration; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; leukocyte migration involved in inflammatory response; natural killer cell activation; neutrophil chemotaxis; neutrophil migration; phagocytosis; phagocytosis, engulfment; positive regulation of angiogenesis; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of neutrophil degranulation; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of superoxide anion generation; receptor clustering; receptor internalization; receptor-mediated endocytosis; regulation of peptidyl-tyrosine phosphorylation
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Reference #:
P11835
(UniProtKB)
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Alt. Names/Synonyms: 2E6; AI528527; Cd18; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; integrin beta 2; Integrin beta-2; ITB2; Itgb2; LAD; LCAMB; Lfa1; lymphocyte function associated antigen 1; Mac-1 beta; macrophage antigen-1 beta; MF17; OTTMUSP00000021575
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Gene Symbols: Itgb2
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Molecular weight:
85,026 Da
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Basal Isoelectric point:
7.02
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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